NASA’s Space Biology Program within the agency’s Biological and Physical Sciences division conducts research across a wide spectrum of biological organization and model systems to probe underlying mechanisms by which organisms acclimate to stressors encountered during space exploration (including microgravity, ionizing radiation, and elevated concentrations of carbon dioxide). This research informs how biological systems regulate and sustain growth, metabolism, reproduction, and development in space and how they repair damage and protect themselves from infection and disease.